MRI phantom compensates for temperature and pressure

Modus Medical Devices has developed an MRI quality assurance (QA) device that can compensate for variations in temperature or pressure (WO/2017/120662). The MRI phantom comprises a container, made of a rigid MR-invisible material with a known 2D or 3D geometry, incorporating one or more sealed reservoirs containing fluid that produces an MRI signal. Each reservoir has a first volume portion, connected to a second variable volume portion. This second portion accommodates changes in the volume of fluid within the sealed reservoir due to fluctuations in temperature and/or pressure. The phantom is particularly suitable for image-guided therapy applications, where high geometrical accuracy of the MRI equipment is essential.

Novel compound enables PET imaging of Alzheimer's

Neuboron Medtech of China has published details of a compound that specifically binds with β amyloid protein, making the treatment and diagnosis of Alzheimer's disease more targeted (WO/2017/114317). The compound contains a nuclide with a large cross section for capturing thermal neutrons and is capable of specifically binding with β amyloid protein. The nature of the compound allows it to be used in conjunction with a neutron capturing therapeutic apparatus to eliminate β amyloid protein. When marked using 11C, the compound can be used in conjunction with PET/CT to determine the part of the brain in which β amyloid protein is deposited, thus enabling diagnosis of Alzheimer's disease. The filing also discloses a preparation method for the compound.

Machine-learning approach cleans up biosignals

A team from the University of California has devised methods for processing biosignals, such as transcranial Doppler ultrasound measurements of intracranial pressure, for example. The approach is particularly suitable for reducing noise and artefacts in continuously monitored quasi-periodic biosignals without prior knowledge of the noise distribution (WO/2017/124044). The signal-processing framework trains a subspace manifold with reference signals. Subsequent signals are projected onto the trained manifold and adjusted based on the nearest neighbours of the state of the sample being projected, as well as the state of the sample at the previous time point. A denoised or modified output is obtained with inverse mapping.

ECG system differentiates diagnoses for athletes

An electrocardiogram (ECG) is used to help detect abnormal cardiovascular conditions that may lead to sudden cardiac arrest. However, an athlete performing regular, intense physical training may exhibit electrical manifestations in the heart that would be considered abnormal in the general population. Philips has now created an ECG diagnostic system with non-athletic and an athletic ECG diagnostic modes that should minimize, or prevent, false positive abnormal ECG interpretations in highly trained athletes (WO/2017/121729). The system employs an ECG wave controller that generates an ECG wave in response to one or more electrode signals. In response, the ECG diagnostic controller classifies the wave as either a non-athletic or an athletic ECG wave. The ECG wave is then interpreted as being normal or abnormal, based on different diagnostic criteria for non-athlete and athlete classifications.

Device applies scintillator directly onto sensor panel

Agfa HealthCare has invented a method for applying scintillator particles directly onto a sensor panel that contains an array of photoelectric conversion elements and surrounding electronic components, thereby maximizing the area for conversion of X-rays into electrical signals and providing uniform coating thickness at the periphery of the scintillator layer (WO/2017/108492). The sensor panel is coated with a dispersion of scintillator particles using a coating device, which comprises a carriage containing a blade connected to a pair of opposing side-walls. The height of the side-walls is adjustable to obtain a first gap between the underside of the side-walls and the surface of the support. The blade is connected such that a second gap is obtained between the blade and the support. The desired coating thickness is obtained by adjusting the gap between the upper surface of the sensor panel and the blade.

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